The influence of choline and geranic acid-based ionic liquids (CAGE ILs) on the anticancer activity of selected Pt(ii) and Pt(iv) complexes was investigated. All complexes exhibited appreciable solubility in CAGE ILs, with Pt(ii) complexes 2 and 4 undergoing immediate ligand substitution. In contrast, the hydrophobic derivative 3 demonstrated remarkable stability for up to 48 hours. 19F-1H HOESY NMR analysis revealed that 3 localized within the hydrophobic regions of CAGE 1 : 2 (choline:geranate). When tested in U87-MG glioblastoma cells, CAGE ILs enhanced the anticancer activity of the Pt complexes. Notably, complex 3 exhibited a significant increase in cytotoxicity, nearly completely reducing cell viability when formulated with CAGE IL.
Verdugo, M., Sierri, G., Hernandez-Fernandez, L., Formoso, E., Miranda, J., Sica, F., et al. (2025). Choline-geranate (CAGE) ionic liquids potentiate the anticancer activity of platinum-based drugs. CHEMICAL COMMUNICATIONS, 61(65), 12167-12170 [10.1039/d5cc02226f].
Choline-geranate (CAGE) ionic liquids potentiate the anticancer activity of platinum-based drugs
Re F.;
2025
Abstract
The influence of choline and geranic acid-based ionic liquids (CAGE ILs) on the anticancer activity of selected Pt(ii) and Pt(iv) complexes was investigated. All complexes exhibited appreciable solubility in CAGE ILs, with Pt(ii) complexes 2 and 4 undergoing immediate ligand substitution. In contrast, the hydrophobic derivative 3 demonstrated remarkable stability for up to 48 hours. 19F-1H HOESY NMR analysis revealed that 3 localized within the hydrophobic regions of CAGE 1 : 2 (choline:geranate). When tested in U87-MG glioblastoma cells, CAGE ILs enhanced the anticancer activity of the Pt complexes. Notably, complex 3 exhibited a significant increase in cytotoxicity, nearly completely reducing cell viability when formulated with CAGE IL.
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